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Article

Clinicopathological and mutational characteristics of primary double mutant gastrointestinal stromal tumor: a single center study with review of the literature.

BMC cancer - 8 Mar 2023

Yan Jiaqi, He Xin, Shen Chaoyong, Zou Yan, Chen Huijiao, Tang Yuan

Abstract excerpt

AIMS: Primary double KIT/PDGFRA mutations are very rare in gastrointestinal stromal tumours (GISTs) but have not been comprehensively studied to date. In the present study, we investigated the clinicopathologic and genetic features of eight cases of primary double-mutant GISTs, and we reviewed the literature. METHODS AND RESULTS: The tumours occurred in six males and two females (age range 57-83 years) and...

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PMID: 36890498
DOI: 10.1186/s12885-023-10684-x
PMCID: PMC9993699

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