Investigating the causal relationship and mediating mechanisms between Clonal hematopoiesis and vitamin D levels: A Mendelian randomization study.

Abstract excerpt

Clonal hematopoiesis (CH) is defined by the clonal proliferation of hematopoietic cells that acquire somatic mutations in specific driver genes. Growing evidence suggests that vitamin D (VD), beyond its well-established role in calcium and bone homeostasis, also participates in diverse physiological processes, including cell cycle regulation and immune modulation. Although recent studies have suggested a...

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