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Article

Genetic evidence for the causal effect of clonal hematopoiesis on pulmonary arterial hypertension.

BMC cardiovascular disorders - 23 Jan 2025

Qiu Jia-Yong, Huang Shen-Shen, Liu Chao, Ding Dong, Xu Yan-Hong, Mao Yi-Min, Yuan Ya-Dong

Abstract excerpt

BACKGROUND: Pulmonary arterial hypertension (PAH) is a severe and progressive cardiovascular disease. While potential links between clonal hematopoiesis (CH) and cardiovascular diseases have been identified, the causal relationship between CH and PAH remains unclear. This study aims to investigate the causal effect of CH on the risk of PAH using a two-sample Mendelian randomization (MR) approach. METHODS: We...

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Share to Arterial Pressure
Share to Clonal Hematopoiesis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Dioxygenases

Share to DNA Methyltransferase 3A

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Share to Proto-Oncogene Proteins

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Source

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Identifiers

PMID: 39849426
DOI: 10.1186/s12872-025-04475-4
PMCID: PMC11755826

Genes

PAH
TET2
DNMT3A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

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