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Article

Causal association between clonal hematopoiesis indeterminate potential and cancer: a Mendelian randomization study.

Experimental biology and medicine (Maywood, N.J.) - 1 Jan 2026

Jin Juan, Pu Qian, Wu Chengrong, Lei Yu, Hu Yaxin, Yang Xiuju, Huang Jinghui, Wu Fangfang, Xiao Li, Yu Lei

Abstract excerpt

Clonal hematopoiesis of indeterminate potential (CHIP) causes the expansion of mutated hematopoietic stem cells and produces immunophenotypically altered leukocytes, which induce a tumor-promoting inflammatory condition. However, the causal effect of CHIP on cancer remains unclear. We assessed the relationship of genetically predicted CHIP with the risk of 18 cancer types involving 612,576 cases using two-sample...

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Share to Clonal Hematopoiesis
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42577799
DOI: 10.3389/ebm.2026.10923
PMCID: PMC13455644

Genes

DNMT3A
MVP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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