Article
DNMT3A clonal hematopoiesis is associated with cardiovascular disease in women.
Atherosclerosis - 1 Apr 2026
Halmos Benedek, Salzbrunn Jonas B, van Zeventer Isabelle A, de Graaf Aniek O, Miedema Silke E, Vonk Judith M, van der Ende M Yldau, van der Harst Pim, Vliegenthart Rozemarijn, Jansen Joop H, Huls Gerwin, Westerterp Marit
Abstract excerpt
BACKGROUND: Clonal hematopoiesis (CH) is an independent risk factor for cardiovascular disease (CVD). Targeted next generation sequencing (NGS) studies have highlighted the contribution of smaller clones to CVD, particularly for DNMT3A and TET2 CH, the most frequent CH mutations. DNMT3A CH occurs more frequently in women than men. Whether sex affects the association between CH and CVD is unknown. METHODS: We...
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