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Article

Optimizing intervertebral disc cell metabolic phenotyping with machine learning and artificial neural networks.

Scientific reports - 22 Dec 2025

Bahar Md Entaz, Maulidi Rizi Firman, Ngo Quang Nhat, Kim Deok Ryong

Abstract excerpt

Biological phenotyping of cellular metabolism is essential for deciphering health and disease states. The Seahorse XF analyzer enables direct measurement of oxygen consumption rate (OCR) and extracellular acidification rate (ECAR), providing insight into mitochondrial function and glycolytic activity in living cells. Accurate phenotyping requires meticulous preparation, including forming a uniform cell monolayer...

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PMID: 41429816
DOI: 10.1038/s41598-025-28236-7
PMCID: PMC12722773

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