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Reconstructing the Mitochondrial Proton Motive Force Using Physics-Informed Neural Networks and Surrogate Bioenergetic Signals

2025-09-24

Abstract excerpt

The mitochondrial proton motive force (PMF) underlies ATP synthesis, metabolite transport, and energy coupling. Yet, direct measurement of PMF remains technically challenging due to probe invasiveness, calibration drift, and compartmental averaging. Here, we introduce a physics-informed neural network (PINN) framework that reconstructs PMF from surrogate signals including NADH, oxygen, electron flux, proton leak,...

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Literature Corpus work
2e119273-bbf6-5bb2-8b08-9cc08ba04e63
DOI
10.1101/2025.09.19.677356
Open publication

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Reconstructing the Mitochondrial Proton Motive Force Using Physics-Informed Neural Networks and Surrogate Bioenergetic SignalsDOI 10.1101/2025.09.19.677356
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