Genome-scale methods converge on key mitochondrial genes for the survival of human cardiomyocytes in hypoxia.

doi:10.1161/CIRCGENETICS.113.000269

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Article

Genome-scale methods converge on key mitochondrial genes for the survival of human cardiomyocytes in hypoxia.

Circulation. Cardiovascular genetics - 1 Aug 2014

Edwards Lindsay M, Sigurdsson Martin I, Robbins Peter A, Weale Michael E, Cavalleri Gianpiero L, Montgomery Hugh E, Thiele Ines

Abstract excerpt

BACKGROUND: Any reduction in myocardial oxygen delivery relative to its demands can impair cardiac contractile performance. Understanding the mitochondrial metabolic response to hypoxia is key to understanding ischemia tolerance in the myocardium. We used a novel combination of 2 genome-scale methods to study key processes underlying human myocardial hypoxia tolerance. In particular, we hypothesized that...

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Share to Adenosine Triphosphate
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 24873932
DOI: 10.1161/CIRCGENETICS.113.000269

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.