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Article

Whole genome sequencing of nearly isogenic WMI and WLI inbred rats identifies genes potentially involved in depression and stress reactivity.

Scientific reports - 20 Jul 2021

de Jong Tristan V, Kim Panjun, Guryev Victor, Mulligan Megan K, Williams Robert W, Redei Eva E, Chen Hao

Abstract excerpt

The WMI and WLI inbred rats were generated from the stress-prone, and not yet fully inbred, Wistar Kyoto (WKY) strain. These were selected using bi-directional selection for immobility in the forced swim test and were then sib-mated for over 38 generations. Despite the low level of genetic diversity among WKY progenitors, the WMI substrain is significantly more vulnerable to stress relative to the...

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Source

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Identifiers

PMID: 34285244
DOI: 10.1038/s41598-021-92993-4
PMCID: PMC8292482

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