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Article

Compensatory evolution in NusG improves fitness of drug-resistant M. tuberculosis.

Nature - 1 Apr 2024

Eckartt Kathryn A, Delbeau Madeleine, Munsamy-Govender Vanisha, DeJesus Michael A, Azadian Zachary A, Reddy Abhijna K, Chandanani Joshua, Poulton Nicholas C, Quiñones-Garcia Stefany, Bosch Barbara, Landick Robert, Campbell Elizabeth A, Rock Jeremy M

Abstract excerpt

Drug-resistant bacteria are emerging as a global threat, despite frequently being less fit than their drug-susceptible ancestors1-8. Here we sought to define the mechanisms that drive or buffer the fitness cost of rifampicin resistance (RifR) in the bacterial pathogen Mycobacterium tuberculosis (Mtb). Rifampicin inhibits RNA polymerase (RNAP) and is a cornerstone of modern short-course tuberculosis therapy9,10....

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Share to Conserved Sequence
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Drug Resistance, Bacterial

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Identifiers

PMID: 38509362
DOI: 10.1038/s41586-024-07206-5
PMCID: PMC10990936

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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