Article
Kidney tubular epithelial cell ferroptosis links glomerular injury to tubulointerstitial pathology in lupus nephritis
2022-05-28
Abstract excerpt
<h4>Objective</h4> An appreciation of factors that lead to tubular injury in lupus nephritis is lacking. Iron accumulates in the kidney tubules of nephritic patients and lupus-prone nephritic mice. Ferroptosis is a druggable, iron-dependent form of cell death that has received little attention in lupus nephritis. This study investigated whether intra-renal ferroptosis is a target for intervention in lupus nephrit...
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Identifiers and source
- Literature Corpus work
- 29cc415b-ab05-59c5-a252-d3320eedc398
- DOI
- 10.1101/2022.05.26.493579