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Article

Association of the YTHDF2 rs3738067 A>G variant with hepatoblastoma risk: a multicenter case-control study in Chinese children.

BMC cancer - 17 Dec 2025

Wang Zhuo, Zhu Jinhong, Zhang Wenli, Yang Zhonghua, Li Yong, Li Li, Li Suhong, Cheng Jiwen, Zhang Jiao, He Jing, Yi Peng

Abstract excerpt

BACKGROUND: As a rare cancer, hepatoblastoma is the most prevalent malignant liver tumor in children, yet its underlying causes are poorly understood. YTHDF2, a canonical m⁶A reader, regulates mRNA stability and decay, and its dysregulation has been implicated in tumorigenesis across multiple malignancies. Whether YTHDF2 polymorphisms influence hepatoblastoma risk is unclear. This multicenter case-control study...

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Identifiers

PMID: 41408219
DOI: 10.1186/s12885-025-15478-x
PMCID: PMC12822027

Genes

YTHDF2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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