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Article

Multiancestry Transcriptome-Wide Association Study Identifies Candidate Genes Associated with Hepatoblastoma.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Aug 2025

Xie Tiankai, Sorenson Josey C, Spector Logan G, Pankratz Nathan, Huang R Stephanie, Hiyama Eiso, Poynter Jenny N, Tomlinson Gail E, Armengol Carolina, Kappler Roland, Scheurer Michael E, Roman Eve, Castellano Aurora, Grotzer Michael A, Ziegler David S, Basu Saonli, Marcotte Erin L, Yang Tianzhong

Abstract excerpt

BACKGROUND: Hepatoblastoma (HB) is a rare embryonal liver tumor, with an increasing global incidence that underscores the need to understand its genetic etiology. METHODS: Utilizing the ancestry-matched expression quantitative loci data, we performed a HB transcriptome-wide association study (TWAS) on 4,539 Europeans, 1,047 Latinos, and 378 African Americans (∼1:10 case-control ratio). We conducted a...

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Identifiers

PMID: 40465396
DOI: 10.1158/1055-9965.EPI-24-1553
PMCID: PMC13418932

Genes

FADS1
IMPACT
OXER1
UGDH

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