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Article

Association of the pri-miR-34b/c rs4938723 T > C polymorphism with hepatoblastoma susceptibility in Eastern Chinese children: A five-center case-control study.

BMC medical genomics - 1 Jul 2025

Zhang Wenli, Zhu Jinhong, Bian Jun, Zhou Chunlei, Zhang Shouhua, He Shaohua, Lu Hongting, Wang Yizhen, He Jing

Abstract excerpt

BACKGROUND: Hepatoblastoma is the most prevalent liver cancer affecting children, and its intricate causes are closely linked to genetic variations. This study interrogated the influence of the miR-34b/c rs4938723 T > C polymorphism in hepatoblastoma predisposition in a Han Chinese children study population, comprising 193 cases and 773 controls from East China. METHODS: Genotyping was performed via the TaqMan...

Read the complete abstract on PubMed

Topics

Child
Child, Preschool
Female

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Humans

Infant

Male

Case-Control Studies

China

Genetic Association Studies

Genetic Predisposition to Disease

Hepatoblastoma

Liver Neoplasms

MicroRNAs

Polymorphism, Single Nucleotide

East Asian People

Source

Open in PubMed Open full text

Identifiers

PMID: 40598293
DOI: 10.1186/s12920-025-02179-4
PMCID: PMC12211766

Genes

LAYN
PPP2R1B

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 20 Oct 2026.

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