Article
YTHDC1 gene polymorphisms and hepatoblastoma susceptibility in Chinese children: A seven-center case-control study.
The journal of gene medicine - 1 Nov 2020
Chen Huitong, Li Yong, Li Li, Zhu Jinhong, Yang Zhonghua, Zhang Jiao, Li Suhong, Xin Yijuan, Xia Huimin, He Jing
Abstract excerpt
BACKGROUND: Hepatoblastoma is a commonly occurring embryonal tumors in children. N6-methyladenosine (m6 A) plays a critical role in gene expression, thus contributing to the occurrence and progression of cancer. RNA splicing is regulated by the nuclear m6 A reader YTHDC1, yet the roles of YTHDC1 polymorphisms in hepatoblastoma remain unclear. METHODS: We conducted a seven-center case-control study to determine...
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