Characterization of the expression and function of schizophrenia risk gene Dtnbp1 in the suprachiasmatic nucleus.

Abstract excerpt

Schizophrenia (SZ) is a debilitating neurodevelopmental disorder with environmental and genetic origins. Circadian rhythm disruption is observed in a large proportion of patients with SZ. We previously found that Sandy (Sdy) mice, which carry a mutation in the SZ-associated gene dystrobrevin binding protein 1 (Dtnbp1, also called Dysbindin-1), show altered rhythms of locomotor activity. To address the possible...

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