Article
Constant light uncovers behavioral effects of a mutation in the schizophrenia risk gene Dtnbp1 in mice.
Behavioural brain research - 1 May 2015
Bhardwaj Sanjeev K, Stojkovic Katarina, Kiessling Silke, Srivastava Lalit K, Cermakian Nicolas
Abstract excerpt
Various psychiatric disorders, including schizophrenia, are comorbid with sleep and circadian rhythm disruptions. To understand the links between circadian rhythms and schizophrenia, we analyzed wheel-running behavior of Sandy (Sdy) mice, which have a loss-of-function mutation in the schizophrenia risk gene Dtnbp1, and exhibit several behavioral features of schizophrenia. While rhythms of Sdy mice were mainly...
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