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Article

Genetic and neuroanatomical correlates of bipolar disorder in high-risk youth.

BMJ mental health - 16 Jan 2026

Wang Jie, Liu Xiaodong, Lam Bess Yin-Hung, Lu Weicong, Shao Robin, Li Xiaoyue, Wang Runhua, Xu Fanyong, Chen Jinyong, Cai Aoling, Goldstein Benjamin, Du Fei, McIntyre Roger S, Wu Jinfeng, Lin Kangguang

Abstract excerpt

OBJECTIVES: Bipolar disorder (BD) often begins in adolescence, a period marked by dynamic neurodevelopment. However, the neurobiological basis from genetic risk and subthreshold symptoms to diagnosed BD remains unclear. METHODS: We conducted a cross-sectional analysis using data from the Recognition and Early Intervention of Prodromal Bipolar Disorders cohort (NCT01863628), including 392 participants aged 12-25...

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Magnetic Resonance Imaging
Bipolar Disorder
Cerebral Cortex
Cross-Sectional Studies
Multicenter Studies as Topic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Prodromal Symptoms

Randomized Controlled Trials as Topic

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Identifiers

PMID: 41545228
DOI: 10.1136/bmjment-2025-302006
PMCID: PMC12815174

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