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Article

Interaction between adverse childhood experiences and polygenic risk in patients with bipolar disorder.

Translational psychiatry - 22 Sept 2020

Park Young-Min, Shekhtman Tatyana, Kelsoe John R

Abstract excerpt

The interaction between genes and environment often occurs when they depend on one another. We hypothesized that adverse childhood experiences (ACEs) would interact with genetic predispositions to bipolar disorder (BD), demonstrating earlier age at onset (AAO) and worse clinical outcomes. We aimed to clarify the effects of the interaction between ACEs and genetic susceptibility using polygenic risk score (PRS) on...

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Source

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Identifiers

PMID: 32963226
DOI: 10.1038/s41398-020-01010-1
PMCID: PMC7509781

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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