Article
Structural neuroimaging phenotypes of a novel multi-gene risk score in youth bipolar disorder.
Journal of affective disorders - 15 Jun 2021
Cazes Jaime, Dimick Mikaela K, Kennedy Kody G, Fiksenbaum Lisa, Zai Clement C, Patel Ronak, Islam Alvi H, Tampakeras Maria, Freeman Natalie, Kennedy James L, MacIntosh Bradley J, Goldstein Benjamin I
Abstract excerpt
BACKGROUND: Bipolar disorder (BD) is among the most heritable psychiatric disorders, particularly in early-onset cases, owing to multiple genes of small effect. Here we examine a multi-gene risk score (MGRS), to address the gap in multi-gene research in early-onset BD. METHODS: MGRS was derived from 34 genetic variants relevant to neuropsychiatric diseases and related systemic processes. Multiple MGRS were...
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