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Article

Biotypes of deeply phenotyped depressed patients reflect signatures of adverse childhood experience and depressive cognitive biases.

Journal of affective disorders - 15 Apr 2026

Colombo Federica, Calesella Federico, Bravi Beatrice, Fortaner-Uyà Lidia, Monopoli Camilla, Cazzella Tommaso, Acconcia Michele, Zanardi Raffaella, Colombo Cristina, Carminati Matteo, Fabbri Chiara, Serretti Alessandro, Bollettini Irene, Benedetti Francesco, Poletti Sara, Vai Benedetta

Abstract excerpt

BACKGROUND: Negative Cognitive Styles (NCS) are key features of depression contributing to severe clinical outcomes by sustaining negative affect. However, depression is clinically heterogeneous, reflecting complex neurobiological and environmental interactions. Characterizing heterogeneity using multimodal data could help identify mechanisms mapping onto different phenotypes and discover high-impact biomarkers....

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PMID: 41475572
DOI: 10.1016/j.jad.2025.121080

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