Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Disentangling the relationship between glucose, insulin and brain health: A UK Biobank study.

Diabetes, obesity & metabolism - 1 Mar 2026

Mason Andrew C, Fatih Nasri, Sofat Reecha, Rentsch Christopher T, Smeeth Liam, Bhaskaran Krishnan, Chaturvedi Nish, Garfield Victoria

Abstract excerpt

BACKGROUND: Glycaemic traits are associated with poorer brain health and dementia risk. Recent advances in genetic instruments for specific glycaemic markers enable an in-depth investigation of the likely nature of associations and underlying mechanisms between diabetes-related mechanisms and brain health and dementia. METHODS: We used two-sample Mendelian randomisation (MR) in the UK Biobank (UKB) (maximum...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biological Specimen Banks
Share to Blood Glucose

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fasting

Share to Insulin

Share to Insulin Resistance

Share to Mendelian Randomization Analysis

Share to UK Biobank

Share to United Kingdom

Source

Open in PubMed Open full text

Identifiers

PMID: 41388643
DOI: 10.1111/dom.70353
PMCID: PMC12890726

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Disentangling the relationship between glucose, insulin and brain health: A UK Biobank study.PMID 41388643Read ↗

The relationship between glycaemia, cognitive function, structural brain outcomes and dementia: A Mendelian randomization study in the UK BiobankSemantic proximity Read ↗

Relationship Between Glycemia and Cognitive Function, Structural Brain Outcomes, and Dementia: A Mendelian Randomization Study in the UK Biobank.Semantic proximity Read ↗

Causal Effects of Type 2 Diabetes and Glycemic Traits on Dementia and Stroke: A Mendelian Randomization Study including Imaging EndpointsSemantic proximity Read ↗

Data-driven subtypes of type 2 diabetes mellitus and risk of dementia, stroke, and brain structural changes in the UK BiobankSemantic proximity Read ↗

Testing for associations between HbA1c levels, polygenic risk, and brain health in UK Biobank (N=39,283)Semantic proximity Read ↗

Triglyceride-Glucose Indices, Genetic Susceptibility, and Incident Dementia Risk Across Early CKM Syndrome Stages: A UK Biobank Prospective Cohort StudySemantic proximity Read ↗

Interrogating the complex relationship between Alzheimer’s disease and blood pressure: two instrumental variable approaches to focus on pre-clinical stages of Alzheimer’s disease in UK BiobankSemantic proximity Read ↗

A multivariable Mendelian randomisation study of serum lipids and dementia risk within the UK BiobankSemantic proximity Read ↗

Evaluating the causal association between type 2 diabetes and Alzheimer's disease: a Two-Sample Mendelian Randomisation StudySemantic proximity Read ↗

The causal effect of HbA1c on white matter brain aging by two-sample Mendelian randomization analysisSemantic proximity Read ↗

Peripheral versus Central Index of Metabolic Dysfunction and Associations with Clinical and Pathological Outcomes in Alzheimer's Disease.Semantic proximity Read ↗

Associations of Insulin Sensitivity with Risk of All-Cause and Cause-Specific Dementia: A Prospective Cohort Study.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.