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Relationship Between Glycemia and Cognitive Function, Structural Brain Outcomes, and Dementia: A Mendelian Randomization Study in the UK Biobank.

Diabetes - 1 Oct 2021

Garfield Victoria, Farmaki Aliki-Eleni, Fatemifar Ghazaleh, Eastwood Sophie V, Mathur Rohini, Rentsch Christopher T, Denaxas Spiros, Bhaskaran Krishnan, Smeeth Liam, Chaturvedi Nish

Abstract excerpt

We investigated the relationship between glycemia and cognitive function, brain structure and incident dementia using bidirectional Mendelian randomization (MR). Data were from the UK Biobank (n = ∼500,000). Our exposures were genetic instruments for type 2 diabetes (157 variants) and HbA1c (51 variants) and our outcomes were reaction time (RT), visual memory, hippocampal volume (HV), white matter hyperintensity...

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PMID: 33632741
DOI: 10.2337/db20-0895

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