Article
Peripheral versus Central Index of Metabolic Dysfunction and Associations with Clinical and Pathological Outcomes in Alzheimer's Disease.
Journal of Alzheimer's disease : JAD - 1 Jan 2017
McLimans Kelsey E, Webb Joseph L, Anantharam Vellareddy, Kanthasamy Anumantha, Willette Auriel A
Abstract excerpt
BACKGROUND/OBJECTIVE: Insulin-like growth factor binding protein 2 (IGFBP-2) regulates blood glucose levels, facilitates hippocampal synaptic plasticity and may have a predictive value for Alzheimer's disease (AD) diagnosis. METHODS: IGFBP-2 levels were studied in plasma in 566 subjects and in ce...
Topics
- Aged
- Alzheimer Disease
- Apolipoprotein E4
- Biomarkers
- Brain
- Cognition
- Cognitive Dysfunction
- Female
- Glucose
- Gray Matter
- Humans
- Inflammation
- Insulin Resistance
- Insulin-Like Growth Factor Binding Protein 2
- Linear Models
- Male
- Polymorphism, Single Nucleotide
- Regression Analysis