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The causal effect of HbA1c on white matter brain aging by two-sample Mendelian randomization analysis

11 Jan 2024

Abstract excerpt

Background Poor glycemic control with elevated levels of hemoglobin A1c (HbA1c) is associated with increased risk of cognitive impairment, with potentially varying effects between sexes. However, the causal impact of poor glycemic control on white matter brain aging in men and women is uncertain. Methods We used two nonoverlapping data sets from UK Biobank cohort: gene-outcome group (with neuroimaging data, (N =...

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PMID: 38274506
DOI: 10.3389/fnins.2023.1335500

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