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Associations of Insulin Sensitivity with Risk of All-Cause and Cause-Specific Dementia: A Prospective Cohort Study.

Molecular neurobiology - 18 Jul 2026

Fu Yan, Gao Pei-Yang, Xu Wei, Tan Lan

Abstract excerpt

Impaired insulin sensitivity has been implicated in neurodegeneration, but whether clinically accessible indices of insulin sensitivity predict dementia risk in the general population remains unclear. We examined associations of the estimated glucose disposal rate (eGDR), a validated marker of insulin sensitivity, with incident all-cause dementia (ACD), Alzheimer's disease (AD), and vascular dementia (VaD), and...

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PMID: 42470526
DOI: 10.1007/s12035-026-06032-2

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ACD

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