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Article

Neoantigenic properties of TP53 variants influence cancer risk in individuals with Li-Fraumeni syndrome.

EBioMedicine - 1 Jan 2026

Montellier Emilie, Manches Olivier, Gaucher Jonathan, Freycon Claire, Hoyos David, Blanchet Sandrine, Verboom Murielle, Dutzmann Christina M, Coutant Sophie, Bou Jacqueline, Fin Bertrand, Olaso Robert, Deleuze Jean-François, Frébourg Thierry, Greenbaum Benjamin D, Levine Arnold J, Kratz Christian P, Bougeard Gaëlle, Hainaut Pierre

Abstract excerpt

BACKGROUND: Li-Fraumeni Syndrome (LFS) is a heterogenous cancer predisposition condition caused by pathogenic TP53 variants, characterised by a lifelong high risk of a broad spectrum of cancers. Certain pathogenic TP53 variants have been shown be immunogenic in a somatic context. Whether neoantigenicity contributes to LFS heterogeneity is unknown. In this study we analysed the correlations between predicted...

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Identifiers

PMID: 41370968
DOI: 10.1016/j.ebiom.2025.106065
PMCID: PMC12752760

Genes

TP53

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 11 Sept 2026.

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