Article
MHC-I Genotype Restricts the Oncogenic Mutational Landscape.
Cell - 30 Nov 2017
Marty Rachel, Kaabinejadian Saghar, Rossell David, Slifker Michael J, van de Haar Joris, Engin Hatice Billur, de Prisco Nicola, Ideker Trey, Hildebrand William H, Font-Burgada Joan, Carter Hannah
Abstract excerpt
MHC-I molecules expose the intracellular protein content on the cell surface, allowing T cells to detect foreign or mutated peptides. The combination of six MHC-I alleles each individual carries defines the sub-peptidome that can be effectively presented. We applied this concept to human cancer, hypothesizing that oncogenic mutations could arise in gaps in personal MHC-I presentation. To validate this hypothesis,...
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