Article

Shared inheritance reveals landscape of somatic and germline cancer risk in <i>TP53</i>

2026-04-11

Abstract excerpt

Pathogenic variants in TP53 , the key tumour-suppressor gene underlying Li-Fraumeni syndrome (LFS), are among the best-established causes of inherited cancer predisposition. However, large-scale sequencing has revealed that many apparently pathogenic TP53 variants detected in blood are the result of somatic clonal expansions, complicating risk interpretation. Using blood-derived whole-exome data from 469,391 UK...

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Literature Corpus work: e7fbf9cf-e567-5e5c-a0b6-29c60e4c0d29
DOI: 10.64898/2026.04.10.26350605

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