Neoantigenic properties of<i>TP53</i>variants modify cancer risk in individuals with Li-Fraumeni syndrome

Abstract excerpt

<h4>STRUCTURED ABSTRACT</h4> <h4>Importance</h4> Li-Fraumeni Syndrome (LFS) is an heterogenous cancer predisposition caused by pathogenic TP53 variants, characterized by a lifelong high risk of a broad spectrum of cancers. At least certain pathogenic TP53 variants have been shown be immunogenic in a somatic context. Whether neoantigenicity contributes to the heterogeneity of LFS is unknown. <h4>Objective</h4> To a...

Topics

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• Gene Frequency
• Genetic Association Studies
• Histocompatibility Antigens Class I
• Li-Fraumeni Syndrome
• Mutation, Missense
• Neoplasms
• Tumor Suppressor Protein p53
• Young Adult

Identifiers and source

Literature Corpus work

e327624c-cf5a-5648-8c24-29fceec35a05

DOI

10.1101/2025.06.24.25328545