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Article

Accounting for proximal variants improves neoantigen prediction.

Nature genetics - 1 Jan 2019

Hundal Jasreet, Kiwala Susanna, Feng Yang-Yang, Liu Connor J, Govindan Ramaswamy, Chapman William C, Uppaluri Ravindra, Swamidass S Joshua, Griffith Obi L, Mardis Elaine R, Griffith Malachi

Abstract excerpt

Recent efforts to design personalized cancer immunotherapies use predicted neoantigens, but most neoantigen prediction strategies do not consider proximal (nearby) variants that alter the peptide sequence and may influence neoantigen binding. We evaluated somatic variants from 430 tumors to understand how proximal somatic and germline alterations change the neoantigenic peptide sequence and also affect neoantigen...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 30510237
DOI: 10.1038/s41588-018-0283-9
PMCID: PMC6309579

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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