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Article

Evaluation of Sex-Stratified Polygenic Risk Scores for Type 2 Diabetes Mellitus and Glycemic Traits in the Framingham Heart Study.

Diabetes & metabolism journal - 1 Jul 2026

Wang Ningyuan, Zhang Yixin, Schroeder Philip, Huerta-Chagoya Alicia, Mandla Ravi, Meigs James B, Manning Alisa K, Liu Ching-Ti, Dupuis Josée, Mercader Josep M

Abstract excerpt

BACKGRUOUND: Diabetes is a multifactorial disease with significant genetic predisposition. Polygenic risk scores (PRS) have been developed to estimate an individual's genetic risk of a disease. Traditionally, PRS utilize sex-combined genome-wide association studies (GWAS) due to the limited availability of sex-stratified summary statistics. This study explores sex-dimorphic genetic effects and evaluates the...

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Identifiers

PMID: 41360390
DOI: 10.4093/dmj.2025.0557
PMCID: PMC13366129

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