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Sex specific genomic insights into type 1 diabetes through GWAS and single cell transcriptome analysis.

Diabetes research and clinical practice - 1 Apr 2026

Qu Hui-Qi, Ostberg Kayleigh, Slater Diana J, Wang Fengxiang, Snyder James, Hou Cuiping, Connolly John J, March Michael, Glessner Joseph T, Kao Charlly, Hakonarson Hakon

Abstract excerpt

AIMS: Type 1 diabetes (T1D) exhibits sex differences in genetic risk, yet most genetic studies treat sex as a covariate rather than a modifier of risk. We hypothesized that sex-stratified genome-wide association studies (GWAS) would uncover sex-specific genetic architecture and improve risk prediction. METHODS: We performed GWAS in 6,599 T1D cases (3,483 males, 3,109 females, 7 undetermined) and 12,350 controls...

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PMID: 41724362
DOI: 10.1016/j.diabres.2026.113181

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

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