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Screening of high glucose tolerant Escherichia coli for L-valine fermentation by autonomous evolutionary mutation.

Applied microbiology and biotechnology - 21 Jan 2025

Zhang Li, Cheng Zhijie, Jiang Jing, Zhou Xinyu, Han Longjun, Yang Lei, Gao Jian

Abstract excerpt

L-valine holds wide-ranging applications in medicine, food, feed, and various industrial sectors. Escherichia coli, a pivotal strain in industrial L-valine production, features a concise fermentation period and a well-defined genetic background. This study focuses on mismatch repair genes (mutH, mutL, mutS, and recG) and genes associated with mutagenesis (dinB, rpoS, rpoD, and recA), employing a high-glucose...

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Identifiers

PMID: 39836325
DOI: 10.1007/s00253-024-13334-9
PMCID: PMC11750901

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