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Article

Improvement of isopropanol tolerance of Escherichia coli using adaptive laboratory evolution and omics technologies.

Journal of biotechnology - 10 Aug 2017

Horinouchi Takaaki, Sakai Aki, Kotani Hazuki, Tanabe Kumi, Furusawa Chikara

Abstract excerpt

Isopropanol (IPA) is the secondary alcohol that can be dehydrated to yield propylene. To produce IPA using microorganisms, a significant issue is that the toxicity of IPA causes retardation or inhibition of cell growth, decreasing the yield. One possible strategy to overcome this problem is to improve IPA tolerance of production organisms. For the understanding of tolerance to IPA, we performed parallel adaptive...

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PMID: 28645581
DOI: 10.1016/j.jbiotec.2017.06.408

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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