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Improvement of isopropanol tolerance of Escherichia coli using adaptive laboratory evolution and omics technologies.

Journal of biotechnology - 10 Aug 2017

Horinouchi Takaaki, Sakai Aki, Kotani Hazuki, Tanabe Kumi, Furusawa Chikara

Abstract excerpt

Isopropanol (IPA) is the secondary alcohol that can be dehydrated to yield propylene. To produce IPA using microorganisms, a significant issue is that the toxicity of IPA causes retardation or inhibition of cell growth, decreasing the yield. One possible strategy to overcome this problem is to improve IPA tolerance of production organisms. For the understanding of tolerance to IPA, we performed parallel adaptive...

Topics

2-Propanol
Biosynthetic Pathways
Directed Molecular Evolution
Drug Resistance, Bacterial
Energy Metabolism
Escherichia coli
Escherichia coli Proteins
Gene Expression Profiling
Gene Expression Regulation, Bacterial
Ligases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

RNA-Binding Proteins

Sequence Analysis, RNA

Source

Identifiers

PMID: 28645581
DOI: 10.1016/j.jbiotec.2017.06.408

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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