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Engineering 2,4-Diacetylphloroglucinol-Hyper-Tolerant Escherichia coli via Adaptive Evolution for Efficient Biosynthesis and an Organic Solvent-Free Downstream Process.

ACS synthetic biology - 21 Aug 2026

Wang Jingnan, Liu Mingyue, Li Cheng, Jiang Bo, Lu Yunhuan, Ma Jiajing, Liu Min, Qi Qingsheng, Wang Jichao, Zhao Guang

Abstract excerpt

2,4-Diacetylphloroglucinol (DAPG) is a valuable antimicrobial compound with significant agricultural potential, suffers bioproduction limitations from host toxicity and inefficient downstream processing. This study engineered DAPG-hyper-tolerant Escherichia coli via adaptive laboratory evolution (ALE) starting from a phloroglucinol-tolerant strain. Optimized shake-flask fermentation of evolved Bdt03 yielded...

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PMID: 42429219
DOI: 10.1021/acssynbio.6c00194

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