Article
Spurious genetic associations.
Biological psychiatry - 15 May 2007
Sullivan Patrick F
Abstract excerpt
BACKGROUND: Genetic association studies are widely used in biomedical research and yet only a minority of positive findings stand the test of replication. I explored the capacity of association studies to produce false positive findings and the impact of various definitions of replication. METHODS: Genetically realistic simulation data of a typical genotyping/analytic approach for 10 single nucleotide...
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