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Role of S protein transmembrane domain mutations in the development of occult hepatitis B virus infection.

Emerging microbes & infections - 1 Dec 2022

Jiang Xinyi, Chang Le, Yan Ying, Ji Huimin, Sun Huizhen, Xiao Yingzi, Song Shi, Feng Kaihao, Nuermaimaiti Abudulimutailipu, Wang Lunan

Abstract excerpt

Occult HBV infection (OBI) is a special infection status during Hepatitis B virus (HBV) infection. The underlying mechanism of its occurrence remains unclear. This study conducted sequencing analysis on 104 OBI plasma samples and 524 HBsAg positive samples from 29 blood centres, and searched for high-frequency mutations in transmembrane domain (TMD) of S protein in the OBI population. Plasmids with TMD...

Topics

DNA, Viral
Hepatitis B
Hepatitis B Surface Antigens
Hepatitis B virus
Hepatitis B, Chronic
Humans
Mutation
Phospholipids

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 35976035
DOI: 10.1080/22221751.2022.2114849
PMCID: PMC9518280

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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