Role of core protein mutations in the development of occult HBV infection.

doi:10.1016/j.jhep.2020.12.023

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Article

Role of core protein mutations in the development of occult HBV infection.

Journal of hepatology - 1 Jun 2021

Chen Jingna, Liu Bochao, Tang Xi, Zheng Xin, Lu Jinhui, Zhang Ling, Wang Wenjing, Candotti Daniel, Fu Yongshui, Allain Jean-Pierre, Li Chengyao, Li Linhai, Li Tingting

Abstract excerpt

BACKGROUND & AIMS: Occult HBV infection (OBI) is associated with transfusion-transmitted HBV infection and hepatocellular carcinoma. Studies on OBI genesis have concentrated on mutations in the S region and the regulatory elements. Herein, we aimed to determine the role of mutations in the core region on OBIs. METHODS: An OBI strain (SZA) carrying 9 amino acid (aa) substitutions in the core protein/capsid (Cp)...

Topics

Adult
Amino Acid Substitution
Animals
Cell Line, Tumor
DNA, Viral
Disease Models, Animal
Female
Genotype
Hepatitis B
Hepatitis B Core Antigens
Hepatitis B Surface Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Hepatitis B e Antigens

Hepatitis B virus

Humans

Mice

Mice, Inbred BALB C

Mutagenesis, Site-Directed

Mutation

Source

Open in PubMed

Identifiers

PMID: 33453326
DOI: 10.1016/j.jhep.2020.12.023

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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