Mutant p53 regulates reversible subtype plasticity in pancreatic cancer.

Abstract excerpt

Loss-of-function mutations in the TP53 gene are the most frequent genetic events in human malignancies. However, the extent to which missense TP53 mutations confer oncogenic gain-of-function (GOF) properties remains incompletely understood. Using genetically defined pancreatic cancer organoid models, we demonstrated that mutant p53 provides a selective growth advantage under acute environmental stress and drives...

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