Article
Selective metabolic regulations by p53 mutant variants in pancreatic cancer.
Journal of experimental & clinical cancer research : CR - 26 Nov 2024
Caporali Sabrina, Butera Alessio, Ruzza Alessia, Zampieri Carlotta, Bantula' Marina, Scharsich Sandra, Ückert Anna-Katerina, Celardo Ivana, Kouzel Ian U, Leanza Luigi, Gruber Andreas, Montero Joan, D'Alessandro Angelo, Brunner Thomas, Leist Marcel, Amelio Ivano
Abstract excerpt
BACKGROUND: Approximately half of all human cancers harbour mutations in the p53 gene, leading to the generation of neomorphic p53 mutant proteins. These mutants can exert gain-of-function (GOF) effects, potentially promoting tumour progression. However, the clinical significance of p53 GOF mutations, as well as the selectivity of individual variants, remains controversial and unclear. METHODS: To elucidate the...
Topics
- Tumor Suppressor Protein p53
- Humans
- Pancreatic Neoplasms
- Mice
- Animals
- Mutation
- Cell Line, Tumor
- Cell Proliferation