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Article

Lipidome atlas of p53 mutant variants in pancreatic cancer.

Biology direct - 11 Apr 2025

Cotton Kian, Comer Charley, Caporali Sabrina, Butera Alessio, Gurres Stephanie, Capradossi Francesco, D'Alessandro Angelo, Amelio Ivano, Niklison-Chirou Maria Victoria

Abstract excerpt

Mutations in the tumour suppressor protein p53 are present in 70% of human pancreatic ductal adenocarcinomas (PDAC), subsequently to highly common activation mutation of the oncogene KRAS. These p53 mutations generate stable expression of mutant proteins, such as p53R175H and p53R273H, which do not retain p53 wild type function. In this study, we investigated the impact of two specific p53 mutant variants on...

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Share to Carcinoma, Pancreatic Ductal
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Tumor Suppressor Protein p53

Source

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Identifiers

PMID: 40217553
DOI: 10.1186/s13062-025-00635-w
PMCID: PMC11992884

Genes

KRAS

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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