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Modeling Mowat-Wilson syndrome with patient iPSCs reveals transcriptional and phenotypic defects in neural progenitors.

Neurobiology of disease - 1 Jan 2026

Musante Ilaria, Gorrieri Giulia, Tamburro Serena, Ferrera Giulia, Baldassari Simona, Fetta Anna, Caraffi Stefano Giuseppe, Vignoli Aglaia, Fiorito Giovanni, Garavelli Livia, Canevini Maria Paola, Cordelli Duccio Maria, Zara Federico, Ricci Emilia, Scudieri Paolo

Abstract excerpt

Zinc finger E-box-binding homeobox 2 (ZEB2) is a key transcription factor involved in multiple aspects of nervous system development, including neuronal specification, migration, and differentiation. Loss-of-function variants in ZEB2 cause Mowat-Wilson syndrome (MWS), a severe neurodevelopmental disorder characterized by intellectual disability, epilepsy, and brain structural abnormalities. In this study, we...

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Identifiers

PMID: 41325909
DOI: 10.1016/j.nbd.2025.107205

Genes

ZEB2
MAP2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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