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Article

Phenotype switching in melanoma cells: MITF regulates the expression of CDH1 through E-boxes in an intronic region.

The Journal of investigative dermatology - 1 Jun 2026

Isac Evangeline Breeta Raja David, Sigurbjörnsdóttir Sara, Dilshat Ramile, Cornell Robert A, Kenny Colin, Steingrímsson Eiríkur

Abstract excerpt

Melanoma cells evade drug treatment by changing their phenotype from proliferative to migrative cells and vice versa in a process known as phenotype switching. The Microphthalmia-associated transcription factor (MITF) is a key regulator of phenotype switching in melanoma. Previous studies have shown that loss of MITF affects the expression of epithelial-to-mesenchymal transition marker genes such as E-cadherin...

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Topics

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 41314510
DOI: 10.1016/j.jid.2025.11.008

Genes

CDH1
MITF
CDH2
TWIST1
ZEB1
SNAI1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 9 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Phenotype switching in melanoma cells: MITF regulates the expression of CDH1 through E-boxes in an intronic region.PMID 41314510Read ↗

ZEB1 controls a lineage-specific transcriptional program essential for melanoma cell state transitionsSemantic proximity Read ↗

ZEB1 controls a lineage-specific transcriptional program essential for melanoma cell state transitionsSemantic proximity Read ↗

MITF reprograms the extracellular matrix and focal adhesion in melanomaSemantic proximity Read ↗

MITF, the Janus transcription factor of melanoma.Semantic proximity Read ↗

MITF reprograms the extracellular matrix and focal adhesion in melanomaSemantic proximity Read ↗

Inducibly decreased MITF levels do not affect proliferation and phenotype switching but reduce differentiation of melanoma cells.Semantic proximity Read ↗

A MAFG~MITF complex drives melanoma phenotype switching and progression.Semantic proximity Read ↗

DNA promoter hypermethylation of melanocyte lineage genes determines melanoma phenotype.Semantic proximity Read ↗

BRN2, a POUerful driver of melanoma phenotype switching and metastasis.Semantic proximity Read ↗

Epigenetic reprogramming by tumor-derived EZH2 gain-of-function mutations promotes aggressive 3D cell morphologies and enhances melanoma tumor growth.Semantic proximity Read ↗

Inhibitor of DNA Binding 4 (ID4) is highly expressed in human melanoma tissues and may function to restrict normal differentiation of melanoma cells.Semantic proximity Read ↗

MITF and PAX3 Play Distinct Roles in Melanoma Cell Migration; Outline of a “Genetic Switch” Theory Involving MITF and PAX3 in Proliferative and Invasive Phenotypes of MelanomaSemantic proximity Read ↗

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