Article
A MAFG~MITF complex drives melanoma phenotype switching and progression.
Nature communications - 21 May 2026
Vera Olga, Martinez Michael, Soto-Vargas Zulaida, Wang Kaizhen, Xu Xiaonan, Mecozzi Nicol, Murikipudi Harini, Ruiz-Buceta Sara, Chadourne Manon, Posorske Benjamin, Angarita Ariana, Bok Ilah, Ulloa Arrieta Juan D, Liu Qian, Kim Yumi, Messina Jane L, Tsai Kenneth Y, Major Michael B, Lau Eric K, Yu Xiaoqing, Ibanez de Caceres Inmaculada, Karreth Florian A
Abstract excerpt
Phenotype switching, a key driver of melanoma progression and therapy resistance, is governed by the lineage transcription factor MITF. Here, we identify the small MAF family transcription factor MAFG as a critical regulator of MITF activity and melanoma cell state plasticity. MAFG expression is frequently elevated in melanoma and correlates with poor patient survival. Mechanistically, MAFG binds MITF and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.