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Article

Adaptive Evolution and Distinct Mutation Signatures of Full-Length HBV Quasispecies in HBeAg-Negative Chronic Hepatitis B.

MicrobiologyOpen - 1 Dec 2025

Wu Changhui, Liu Fengwei, Li Xiao, Li Xiaojin, Li Hui, Zhang Sihang, Yan Xiaohui, Zhou Taicheng, Wei Jia

Abstract excerpt

The evolutionary profile of hepatitis B virus (HBV) quasispecies may influence the clinical course of chronic hepatitis B (CHB), but few studies have characterized quasispecies according to hepatitis B e antigen (HBeAg) status. In this study, we analyzed 289 full-length HBV clones from 19 treatment-naïve CHB patients with long-term infection (> 10 years), comprising nine HBeAg-positive and ten HBeAg-negative,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genome, Viral

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Source

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Identifiers

PMID: 41310915
DOI: 10.1002/mbo3.70175
PMCID: PMC12660055

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