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Article

Near extinction of the HBV quasispecies driven by the hard selective sweep in chronic hepatitis B.

mBio - 13 Aug 2025

Lu Daiqiang, He Andong, Liao Guichan, Zhou Renyu, Cheng Zichun, Yip Ka Cheuk, Wang Xiufang, Cao Wei, Peng Jiaojiao, Li Ruiman, Peng Jie, Gao Feng

Abstract excerpt

The viral quasispecies play an important role in pathogenesis. However, little is known about the nature of hepatitis B virus (HBV) quasispecies and its impact on the outcomes of chronic hepatitis B. Here, we characterized the bona fide quasispecies viral populations from 16 chronically infected patients by analyzing the near full-length viral genomes obtained by single genome sequencing. Follow-up plasma samples...

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Share to DNA, Viral
Share to Epitopes, T-Lymphocyte

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genome, Viral

Share to Hepatitis B, Chronic

Share to Hepatitis B virus

Share to Phylogeny

Share to Quasispecies

Share to Selection, Genetic

Source

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Identifiers

PMID: 40586553
DOI: 10.1128/mbio.01113-25
PMCID: PMC12345218

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