Quasispecies structure, cornerstone of hepatitis B virus infection: mass sequencing approach.

Abstract excerpt

Hepatitis B virus (HBV) is a DNA virus with complex replication, and high replication and mutation rates, leading to a heterogeneous viral population. The population is comprised of genomes that are closely related, but not identical; hence, HBV is considered a viral quasispecies. Quasispecies variability may be somewhat limited by the high degree of overlapping between the HBV coding regions, which is especially...

Topics

• Amino Acid Sequence
• Animals
• Antiviral Agents
• Base Sequence
• DNA Mutational Analysis
• Genotype
• Hepatitis B virus
• Hepatitis B, Chronic
• High-Throughput Nucleotide Sequencing
• Humans
• Molecular Sequence Data
• Mutation
• Nucleic Acid Conformation
• Phenotype
• RNA, Viral
• Treatment Outcome