Article
Quasispecies structure, cornerstone of hepatitis B virus infection: mass sequencing approach.
World journal of gastroenterology - 7 Nov 2013
Rodriguez-Frias Francisco, Buti Maria, Tabernero David, Homs Maria
Abstract excerpt
Hepatitis B virus (HBV) is a DNA virus with complex replication, and high replication and mutation rates, leading to a heterogeneous viral population. The population is comprised of genomes that are closely related, but not identical; hence, HBV is considered a viral quasispecies. Quasispecies variability may be somewhat limited by the high degree of overlapping between the HBV coding regions, which is especially...
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