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Article

Germline Mutation Analysis and Real-World Impact in a Selected Cohort of Patients with Non-Small Cell Lung Cancer: INHERITY LC Study.

Clinical lung cancer - 1 Apr 2026

Zurera María, Laguna Juan Carlos, Mezquita Laura, Higuera Oliver, Menao Sebastián, Arruebo María, Jimenez Javier Torres, de Castro Javier, Isla Dolores, Lastra Rodrigo

Abstract excerpt

PURPOSE: Hereditary predisposition has not traditionally been considered a significant risk factor for non-small-cell lung cancer (NSCLC), and germline testing is not routinely established. INHERITY LC is a prospective multicenter study designed to explore the prevalence of germline variants in a selected cohort of patients with NSCLC and to assess the clinical impact of germline testing in NSCLC. METHODS:...

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Source

Identifiers

PMID: 41290502
DOI: 10.1016/j.cllc.2025.10.012

Genes

ATM
BARD1
BRCA2
CHEK2
FAN1
MLH1
MRE11
NBN
PALB2
TP53
XRCC2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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