Article
Clinical and genomic features of Chinese lung cancer patients with germline mutations.
Nature communications - 10 Mar 2022
Peng Wenying, Li Bin, Li Jin, Chang Lianpeng, Bai Jing, Yi Yuting, Chen Rongrong, Zhang Yanyan, Chen Chen, Pu Xingxiang, Jiang Meilin, Li Jia, Zhong Rui, Xu Fang, Chen Bolin, Xu Li, Wang Ning, Huan Jiaojiao, Dai Pingping, Guan Yanfang, Yang Ling, Xia Xuefeng, Yi Xin, Wang Jiayin, Yu Fenglei, Wu Lin
Abstract excerpt
The germline mutation landscape in Chinese lung cancer patients has not been well defined. In this study, sequencing data of 1,021 cancer genes of 1,794 Chinese lung cancer patients was analyzed. A total of 111 pathogenic or likely pathogenic germline mutations were identified, significantly higher than non-cancer individuals (111/1794 vs. 84/10,588, p < 2.2e-16). BRCA1/2 germline mutations are associated with...
Topics
- BRCA1 Protein
- BRCA2 Protein
- China
- Genetic Predisposition to Disease
- Genomics
- Germ-Line Mutation
- Humans
- Lung Neoplasms
- Middle Aged